Role of cytochrome P450 in microsomal oxidataions
Ø The key component in these reaction is cytochromes P450 Labeled because in can unit with carbon monoxide as well as with atmospheric oxygen give a complex with an absorption peak at 450.
Ø Cytochrome P450 is present almost all tissues in the body like lungs, Kindly, skin, Brain, Liver.
Ø But it is not found in these tissues the Microsomal Oxidations do not take place ,because of substrate specificity is very low.
Ø Cytochrome P450 is described as Oxygen carvers.
Ø Cytochrome p450 transfers atmospheric O2 to the substance.
structure
Ø Only reduced form of cytochrome P450 can carry O2 for this way but in the case of it activity it is oxidized to the Fe 3+ form.
Ø The transfers of electrons necessary to effect it change back to the reduced form and so maintain metabolic activity it requires the NICODINMI ADENINE DINUCLEOSIDE PHOSPHATE (NADP/NADPH2) system.
Ø The drug forms a complex with oxidized [FE37] cytochrome p450.
Ø The key component in these reaction is cytochromes P450 Labeled because in can unit with carbon monoxide as well as with atmospheric oxygen give a complex with an absorption peak at 450.
Ø Cytochrome P450 is present almost all tissues in the body like lungs, Kindly, skin, Brain, Liver.
Ø But it is not found in these tissues the Microsomal Oxidations do not take place ,because of substrate specificity is very low.
Ø Cytochrome P450 is described as Oxygen carvers.
Ø Cytochrome p450 transfers atmospheric O2 to the substance.
structure
Ø Only reduced form of cytochrome P450 can carry O2 for this way but in the case of it activity it is oxidized to the Fe 3+ form.
Ø The transfers of electrons necessary to effect it change back to the reduced form and so maintain metabolic activity it requires the NICODINMI ADENINE DINUCLEOSIDE PHOSPHATE (NADP/NADPH2) system.
Ø The drug forms a complex with oxidized [FE37] cytochrome p450.
